Using a nonstick cooking spray, lightly grease a large, shallow baking pan.
In a small bowl, mix the mustard with the mayonnaise, then rub the mixture over the tilapia fillets.
Place both types of bread crumbs in a food processor, along with all the seasonings, and pulse several times until thoroughly combined.
Spread the bread crumbs out on a plate and press both sides of the coated fish into them, ensuring they are fully covered.
Place the breaded fillets on to the baking pan and bake in the oven for around 15 to 18 minutes, until the fish is cooked through. Test for doneness by flaking with a fork - it should flake easily.